Although calories in, calories out is valid, people are not robots. Much of diet science is not on how many calories we should consume (we have that pretty much figured out), but on how we make sure we do it in a way that leaves us satiated and sane. So just commenting on any study about diets with “cico is all that counts” is ignoring a lot of nuance. What is interesting is to learn whether this method of achieving negative cico works for more or less people than other methods.