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I’ve found it depends a lot on the game. In CP2077, DLSS+frame gen looks great to me with full raytracing enabled. But in The Witcher 3, I found frame gen to cause a lot of artifacts, and in PvP games I wouldn’t use regular DLSS/FSR. In general I’ve found the quality preset in DLSS to be mostly indistinguishable from native on 3440x1440, and I’m excited to try FSR 3 when I get the chance.
Honestly, after DOS2, I’d play a Larian game in any setting just based on them being the devs - and that goes double after BG3. Their handle on storytelling and environments is so good I’d trust it would be enjoyable even in a setting I’m not interested in.